Studying Psychological Changes And InflammatoRy MarKers in Premenstrual Dysphoric Disorder (SPARK-PMDD)

Written By Inspire the Mind

Scientists have found that the immune system, the body’s system dedicated to fighting infections, is in a state of “hyperactivity” (i.e., more active than you would normally expect) in some people with depression and postnatal depression, despite the lack of any actual ongoing infection. This response is referred to as inflammation.

This study aims to explore how inflammation in the body may be linked to symptoms of Premenstrual Dysphoric Disorder (PMDD) across the menstrual cycle, and how thoughts, emotions, and behaviours also may change throughout the cycle.

By comparing people with and without PMDD, we hope to gain a better understanding of the biological and psychological factors involved in PMDD, with the goal of improving treatments.

For more information, email us at ellen.r.lambert@kcl.ac.uk or SPARK-PMDD@kcl.ac.uk.

Recruitment : To begin February 2027

Research/Analysis: Ongoing

Take Part

Who can take part? 

You may be eligible if you:

  • ARE female (Assigned female sex at birth (AFAB), with ovaries) 

  • ARE medically healthy 

  • ARE between 18-42 years of age (inclusive) 

  • ARE normally menstruating (having a menstrual period about once per month)

  • ARE registered with a local UK GP

  • ARE a healthy weight (approx. BMI: 18-30kg/m²) 

  • CAN travel to King’s College Hospital twice within one menstrual cycle

  • CAN commit to completing daily diaries for 2 months remotely via smartphone app. 

  • ARE NOT perimenopausal or menopausal

  • ARE NOT taking any hormonal medications, including oral contraceptive pills or Mirena IUD

  • ARE NOT currently pregnant/breastfeeding

  • ARE NOT taking anti-inflammatory medication regularly  

  • DO NOT have a current/historical gynaecological problem (e.g., endometriosis, polycystic ovary syndrome, or have had gynaecological surgery in the past year)

What's involved?

To check you are eligible for the study, interested individuals will:

  • complete a daily diary of PMDD symptoms for one month

  • attend a virtual clinical diagnostic interview with a Clinical Psychologist

If you are eligible, over a two-month period, participants will:

  • complete daily psychological assessments across two menstrual cycles

  • complete ovulation tests from home to confirm menstrual phasing

  • come into King’s College Hospital (KCH) in London twice to provide blood samples to measure inflammation

As a thank you you will be reimbursed up to £80 + travel for your time and efforts




















Inspire the Mind
Next

The CODA Study